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ObjectiveCurrent treatment strategies for acute lower extremity deep vein thrombosis (DVT) have shifted from merely preventing pulmonary embolism to actively removing thrombus and preserving valve function. However, ther...

Coronary artery ectasia (CAE) is a vascular lesion characterized by abnormal dilation of the coronary arteries, with complex pathogenesis and diverse clinical manifestations. CAE can be classified into primary and second...

Exosomes, a specialized class of extracellular vesicles, exhibit significant therapeutic potentials for neurological disorders, in particular for vascular dementia (VaD). VaD is the second most common form of dementia, c...

Thyl Snoeck,1,2 Frédéric Paillaugue,1,2 Steven Provyn1,2 1Department of Physiotherapy, Human Physiology and Anatomy, Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit Brussel, Brussels, Belgi...

Abstract Importance The mortality benefit of lipid-lowering therapies (LLTs) in true primary prevention of cardiovascular disease (CVD) remains uncertain, in part because prior studies frequently included individuals wit...

Abstract Background Epidemiological data consistently associate low vitamin D status with elevated cardiovascular risk, yet causal mechanisms remain contested. Methods This review synthesized evidence through a protocol-...

Conjunctival vascular tumours are rare in adults and often pose diagnostic challenges due to overlapping features between haemangioma and lymphangioma. A 22-year-old male presented with painless, slowly enlarging mass in...

Vascular calcification arises from osteogenic transdifferentiation of vascular smooth muscle cells (VSMC) driven by disordered calcium signaling. Sarcoplasmic/ER calcium ATPase 2 (SERCA2) maintains intracellular calcium ...

Cardiovascular disease (CVD) represents a significant global public health challenge, with its high incidence and mortality rates imposing a substantial socioeconomic burden. Tribbles family proteins (TRIB1, TRIB2, and T...

Abstract Current treatment for atherosclerotic cardiovascular diseases (ASCVD) mainly focuses on the modification of systemic risk factors, such as hyperglycemia and hyperlipidemia. Despite significant efforts and expans...

Maria Hee Jung Park Frausing,1– 3 Morten Schmidt,2,4 Ole Dan Jørgensen,5,6 Frederikke Nørregaard Jakobsen,7 Frederik Mikkelsen,1,2 Jacob Moesgaard Larsen,8 Charlotte Ellen Larroudé,9 Berit Thornvig Philbert,10 Jens ...

Abstract Background The tumor immune microenvironment (TIME) of canine and feline mammary carcinomas (CMC and FMC) comprises a complex collection of immune cells that remains underinvestigated. We performed extensive imm...

IntroductionNurses and nursing assistants working in high-intensity hospital settings are exposed to demanding workloads, organizational pressure, and substantial emotional strain, factors commonly associated with job di...

Abstract Objective To investigate the influence of postoperative pathological factors (including variables not categorized as moderate - to - high - risk factors according to the Sedlis criteria) on the prognosis and lym...

The gut microbiota has co-evolved with its host and forms an essential component of the human body. It is acquired at birth and continues to develop alongside the host, preserving its diversity and stability throughout l...

Limb difference affects millions worldwide, with prevalence expected to rise due to increasing rates of diabetes and vascular disease. Despite the need for high-quality, functional prostheses, many individuals, particula...

Pulmonary hypertension (PH) is a severe cardiopulmonary disorder characterized by pulmonary vascular remodeling, which leads to increased pulmonary vascular resistance (PVR), right ventricular (RV) hypertrophy, and ultim...

Skin lesions are one of the most prevalent form of diseases existing among us. Early detection and classification of potentially malignant skin lesions can give us a lead in the fight against skin cancer. There are many ...

The underlying mechanisms linking age-related hearing loss (HL), and cognitive dysfunction are not well-understood. Traditionally, age-related HL was primarily related to damage of hair cells (i.e., the sensory component...

The current number of emerging contaminants worldwide may reach tens of thousands. However, research on the extra-pulmonary toxicity induced by combined exposure of extremely low-dose emerging pollutants remains extremel...

Enterotoxaemia remains one of the most severe and rapidly fatal diseases affecting goats, mainly caused by Clostridium perfringens types C and D. Despite widespread vaccination practices, the disease continues to produce...

Jiahui Zhang,1– 3,* Junran Tong,1– 3,* Yang Sun,4,* Jinpeng Sun,1– 3 Ran Gao,1– 3 Di Sun,5 Xiaopeng Guo,6 Yumiao Wei1– 3 1Department of Cardiology, Union Hospital, Tongji Medical College...

ABSTRACT Background and Aims May–Thurner Syndrome (MTS) is a rare vascular condition characterized by the compression of the left iliac vein by the overlying right iliac artery. This anatomical anomaly predisposes pati...

Carotid artery stenting (CAS) has emerged as an effective alternative to carotid endarterectomy for treating carotid artery stenosis, particularly in high-risk surgical patients. However, in-stent restenosis (ISR) remain...