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Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols

Ugliarolo, Esteban Ariel et al · Pergamon-Elsevier Science Ltd · 2012

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Autore / responsabile
Ugliarolo, Esteban Ariel et al
Editore
Pergamon-Elsevier Science Ltd
Anno
2012
ISSN
5986-5991
ISSN
5986-5991
Lingua
Inglés

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New chiral purinyl and 8-azapurinyl carbanucleoside derivatives based on indanol were synthesized from commercial available (1S,2S)-trans-1-amino-2-indanol and (1R,2R)-trans-1-amino-2-indanol using a linear methodology. The antiviral activity and cytotoxicity of these compounds were evaluated against herpes simplex virus type 1 (HSV-1) in Vero cells, bovine viral diarrhea virus (BVDV) in Mardin-Darby bovine kidney (MDBK) cells and hepatitis B virus (HBV) in HepG2 2.2.15 cell line. Three compounds, showed an inhibition of the HBsAg levels similar to reference drug lamivudine. One chloropurinyl nucleoside, derived from the cis- 1-amino-2-indanol, was cytotoxic on MDBK cells and it could be a lead for developing anticancer agents. Fil: Ugliarolo, Esteban Ariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Gagey, Dolores. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina

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APA 7

Ugliarolo, E. A. E. A. (2012). Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols. http://hdl.handle.net/11336/161939

MLA

Ugliarolo, Esteban Ariel et al. "Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols." 2012. http://hdl.handle.net/11336/161939.

Chicago

Ugliarolo, Esteban Ariel et al. 2012. "Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols.". http://hdl.handle.net/11336/161939.

Harvard

Ugliarolo, E. A. E. A. 2012, Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols, Pergamon-Elsevier Science Ltd, available at: http://hdl.handle.net/11336/161939 [Accessed 6 Aug. 2026].

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Titolo
Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols
Autore / collaboratori
Ugliarolo, Esteban Ariel et al
Editore
Pergamon-Elsevier Science Ltd
Anno di pubblicazione
2012
ISSN
5986-5991
ISSN
5986-5991
Lingua
Inglés

Soggetti

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ANTIVIRAL AGENTS; CARBANUCLEOSIDES; CYTOTOXICITY; TRANS- AND CIS-1-AMINO-2-INDANOL; VIRUS (HSV-1 BVDV HBV); https://purl.org/becyt/ford/1.6; https://purl.org/becyt/ford/1
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