Polygonatum sibiricum Red. and its polysaccharides in cognitive improvement: Pharmacological mechanisms and therapeutic potential

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Polygonatum sibiricum Red. and its polysaccharides in cognitive improvement: Pharmacological mechanisms and therapeutic potential

Cong Lu et al · Elsevier · 2026

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Autor / responsable

Cong Lu et al

Editorial

Elsevier

Año

2026

ISSN

2095-7548

ISSN

2095-7548

Idioma

eng

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Cognitive impairment is a growing public health concern associated with aging, neurodegenerative diseases, and chronic stress. Polygonatum sibiricum Red. (P. sibiricum, Huang Jing), a traditional Chinese medicinal herb, is used to reinforce qi, strengthen the spleen, and nourish yin. Recent studies have suggested that P. sibiricum polysaccharides (PSP), its major bioactive constituents, exert neuroprotective effects through antioxidant and anti-inflammatory actions, modulation of the gut–brain axis, and improvement of synaptic plasticity. This review summarizes recent advances in the pharmacological activities of P. sibiricum and PSP related to cognitive improvement, highlights findings from behavioral, cellular, and molecular studies, and examines the clinical evidence supporting their therapeutic potential. Understanding the mechanism of action of P. sibiricum offers new insights into its potential development as a functional food or complementary therapeutic agent for cognitive decline.

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APA 7

al, C. L. E. (2026). Polygonatum sibiricum Red. and its polysaccharides in cognitive improvement: Pharmacological mechanisms and therapeutic potential. https://doi.org/10.1016/j.jtcms.2026.03.003

MLA

al, Cong Lu et. "Polygonatum sibiricum Red. and its polysaccharides in cognitive improvement: Pharmacological mechanisms and therapeutic potential." 2026. https://doi.org/10.1016/j.jtcms.2026.03.003.

Chicago

al, Cong Lu et. 2026. "Polygonatum sibiricum Red. and its polysaccharides in cognitive improvement: Pharmacological mechanisms and therapeutic potential.". https://doi.org/10.1016/j.jtcms.2026.03.003.

Harvard

al, C. L. E. 2026, Polygonatum sibiricum Red. and its polysaccharides in cognitive improvement: Pharmacological mechanisms and therapeutic potential, Elsevier, available at: https://doi.org/10.1016/j.jtcms.2026.03.003 [Accessed 23 Jun. 2026].

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Título: Polygonatum sibiricum Red. and its polysaccharides in cognitive improvement: Pharmacological mechanisms and therapeutic potential

Autor / colaboradores: Cong Lu et al

Editorial: Elsevier

Año de publicación: 2026

ISSN: 2095-7548

ISSN: 2095-7548

Idioma: eng

Materias

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Polygonati rhizoma; Polysaccharides; Medicine and food homology; Cognitive impairment; Neuroprotection