Trends in sepsis-related mortality due to dermatologic infections in the United States: Demographic and geographic patterns from 1999 to 2023

Background Dermatologic infections complicated by sepsis represent a significant yet understudied cause of mortality in the United States, with evolving epidemiological patterns that warrant investigation. Objective To examine nationwide trends in sepsis-related mortality due to dermatologic infections from 1999 to 2023, with focus on demographic and geographic disparities. Methods This population-based retrospective study analyzed CDC WONDER mortality data using ICD-10 codes for dermatologic infections with sepsis. Joinpoint regression analysis calculated annual percentage changes (APCs) in age-adjusted mortality rates, stratified by gender, age, race/ethnicity, and geographic region. Results Among 119,837 deaths, overall mortality showed statistically significant rise during 1999-2004 (APC: 9.05%, p<0.001) and 2012-2023 (APC: 4.72%, p<0.001), with a plateau during 2004-2012. Males showed steeper recent increases (2019-2023: APC: 6.64%, p<0.001) than females. The South region experienced the highest sustained increase (2012-2023: APC: 5.19%, p<0.001). Among racial/ethnic groups, Hispanic populations showed the most pronounced variations, with the highest initial increase followed by a statistically significant decline before rising again. Limitations Reliance on death certificate data may introduce coding inconsistencies and underreporting. Conclusion Sepsis-related mortality due to dermatologic infections shows concerning upward trends across most demographic groups and regions, highlighting the need for enhanced prevention strategies and targeted interventions for vulnerable populations.