Multilineage Potential of Adult Human Mesenchymal Stem Cells

Mark F. Pittenger; Alastair M. Mackay; Stephen C. Beck; Rama K. Jaiswal; R. Gordon Douglas; Joseph D. Mosca; Mark A. Moorman; Donald W. Simonetti · Science · 1999

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Mark F. Pittenger; Alastair M. Mackay; Stephen C. Beck; Rama K. Jaiswal; R. Gordon Douglas; Joseph D. Mosca; Mark A. Moorman; Donald W. Simonetti

Editore

Science

Anno

1999

Lingua

Inglés

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Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.

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APA 7

Pittenger, M. F, Mackay, A. M, Beck, S. C, Jaiswal, R. K, Douglas, R. G, Mosca, J. D, Moorman, M. A, & Simonetti, D. W. (1999). Multilineage Potential of Adult Human Mesenchymal Stem Cells. https://doi.org/10.1126/science.284.5411.143

MLA

Pittenger, Mark F, et al. "Multilineage Potential of Adult Human Mesenchymal Stem Cells." 1999. https://doi.org/10.1126/science.284.5411.143.

Chicago

Pittenger, Mark F, Alastair M. Mackay, Stephen C. Beck, Rama K. Jaiswal, R. Gordon Douglas, Joseph D. Mosca, Mark A. Moorman, and Donald W. Simonetti. 1999. "Multilineage Potential of Adult Human Mesenchymal Stem Cells.". https://doi.org/10.1126/science.284.5411.143.

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Pittenger, M. F. et al. 1999, Multilineage Potential of Adult Human Mesenchymal Stem Cells, Science, available at: https://doi.org/10.1126/science.284.5411.143 [Accessed 7 Aug. 2026].

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Titolo: Multilineage Potential of Adult Human Mesenchymal Stem Cells

Autore / collaboratori: Mark F. Pittenger; Alastair M. Mackay; Stephen C. Beck; Rama K. Jaiswal; R. Gordon Douglas; Joseph D. Mosca; Mark A. Moorman; Donald W. Simonetti

Editore: Science

Anno di pubblicazione: 1999

Lingua: Inglés

Soggetti

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Mesenchymal stem cell; Stem cell transplantation for articular cartilage repair; Stem cell; Adult stem cell; Clinical uses of mesenchymal stem cells; Amniotic stem cells; Biology; Cell biology; Bone marrow; Multipotent Stem Cell; Endothelial stem cell; In vitro