Fabrication and characterization of colon targeted ibuprofen nanoparticles

Aim: The objective of our study was to formulate a nanoparticulate drug delivery system that provides controlled delivery of ibuprofen directly targeting colon leading to optimized dosage, reduced side effects ultimately increasing bioavailability and to explore formulation optimization parameters. Methodology: Colon targeted ibuprofen nanoparticles were prepared by solvent evaporation method. Analysis of formulation was performed for surface morphology, percentage entrapment efficiency, particle size, zeta potential, content uniformity, in vitro drug release and Stability assessment. Result: The ultimate optimized conditions found were 1500rpm, 0.1% W/V Tween 80 stabilizer and 1:10 organic to aqueous ratio. Among 6 formulations of ibuprofen nanoparticles analyzed, F1 (with 0.1% Tween 80 stabilizer) was found to be optimized with highest percentage release 99.64%, mean particle diameter 586 nm, smooth surfaces, 88.36% encapsulation efficiency, zeta potential-49mV and controlled release of drug over 8 hours. Conclusion: The optimized stable formulation F1 results showcased that 1500 rpm, 0.1% W/V Tween 80 stabilizer and 1:10 organic to aqueous ratio are optimized parameters of colon targeted ibuprofen nanoparticles preparation with formulation being cost effective with its remarkable enhancement of bioavailability.