Long-term outcomes of interventional therapy for transplant renal artery stenosis: a 5-year follow-up study

This study evaluated the long-term outcomes of interventional therapy for transplant renal artery stenosis (TRAS). A total of 30 TRAS patients who underwent interventional treatment between February 2017 and September 2020 were included. Graft and recipient survival rates were assessed using the Kaplan-Meier method, and post-interventional changes in renal function and blood pressure were analyzed. The 1-, 3-, and 5-year transplant kidney survival rates in the study group were 93.3%, 83.3%, and 76.7%, respectively. The recipients’ survival rates were 100%, 100%, and 90%, respectively. The serum creatinine levels at 1, 3, and 5 years after intervention were 127.5 (92.0, 156.3) μmol/L, 120.0 (90.4, 159.5) μmol/L, and 123.1 (90.0, 170.2) μmol/L, respectively, which were significantly lower than the pretreatment value of 161.5 (104.5, 194.5) μmol/L (P1 < 0.005; P2 < 0.05; p < 0.05). The systolic blood pressures at 1, 3, and 5 years were 135.0 ± 8.2 mmHg, 130.0 ± 11.6 mmHg, and 130.0 ± 9.8 mmHg, respectively, significantly lower than the pretreatment value of 155.5 ± 8.9 mmHg (P1 < 0.005; P2 < 0.001; P3< < 0.001). The diastolic blood pressures at 1, 3, and 5 years were 81.8 ± 7.9 mmHg, 81.9 ± 7.3 mmHg, and 82.3 ± 5.0 mmHg, respectively, significantly lower than the pretreatment value of 95.1 ± 11.8 mmHg (P1 < 0.001; P2 < 0.005; P3 < 0.005). These results demonstrate that interventional therapy for TRAS provides sustainable long-term benefits in graft survival, renal function, and blood pressure control.