Fibrillary Glomerulonephritis Associated with Thyroid Papillary Microcarcinoma: A Case Report

In this report, we describe a case of fibrillary glomerulonephritis associated with thyroid papillary microcarcinoma arising in a 54-year-old female patient suffering from Hashimoto’s thyroiditis. The patient presented with mild edema and a palpable mass on right thyroid lobe. Examinations revealed 1053 mg daily protein excretion and an approximately 1 cm highly vascularized thyroid nodule. She underwent total thyroidectomy and histopathological examination provided evidence of the encapsulated follicular variant of multifocal thyroid papillary microcarcinoma. Thereafter, percutaneous kidney biopsy identified the fibrillary glomerulonephritis for which renin angiotensin system blockage was targeted and, in time, daily protein excretion decreased. The favorable clinical outcome after treatment of carcinoma suggests that there might be a pathophysiological link between autoimmune/malignant pathology and fibrillary glomerulonephritis development.