Effects of Biocompatible Solutions on Residual Renal Functions in Peritoneal Dialysis Patients: A Prospective Observational Study

OBJECTIVE: Residual renal function (RRF) is an important predictor of patient and dialysis technique survival in both hemodialysis (HD) and peritoneal dialysis (PD). Although there have been some studies conducted recently about the relationship between RRF and standard or biocompatible PD solutions; results are conflicting. Therefore, we aimed to conduct a prospective observational study comparing patients using standard PD solutions with those using biocompatible ones in terms of RRF. MATERIAL and METHODS: Adult PD patients treated for more than three months with daily four times two-liter dwells were included. Patients using standard lactate-based PD solution (Dianeal 1.36%) were called Group-1; and those using biocompatible PD solution (Physioneal 1.36%) Group2. The patients’ body weight, total ultrafiltration, residual urine volume, blood count, biochemical parameters and standard PET results were recorded every three months for a year. Statistical analysis was performed by SPSS for Windows ver.13.0. RESULTS: The groups were similar regarding demographic and biochemical parameters except gender. Serum urea levels at 9th and 12th months were lower in Group-2. Residual urine output decreased in both groups with the decrease more prominent in Group-1 although not statistically significant. CONCLUSION: Biocompatible PD solutions may protect RRF more than standard solutions. However, there is need for randomized prospective controlled studies with larger population of patients about the morbidity and mortality.