Insulin Resistance and Antropometric Measurements in Autosomal Dominant Polycystic Kidney Disease

OBJECTIVES: There are confl icting data regarding the insulin resistance in autosomal dominant polycystic kidney disease(ADPKD) patients. We investigated the relationship between insulin resistance and anthropometric measurements in patients with ADPKD. MATERIAL and METHODS: Thirty-six female and twenty-eight male patients were included. HOMA-IR formula was used for determination of insulin resistance. Body mass index(BMI); neck, midarm, waist and hip circumferences; and skin fold thicknesses (SFT) at biceps triceps, subscapular, umbilical and suprailiac regions were recorded, and total body fat ratios were calculated. Patients were divided into four groups according to their creatinine clearance. RESULTS: Twenty-seven patients (42.18%) had insulin resistance. HbA1c, HOMA-IR, insulin and glucose levels, anthropometric measurements and total body fat ratios were not statistically different among the groups. Total body fat was signifi cantly correlated with HOMA-IR. The best predictor of glucose intolerance was found to be subscapular SFT. BMIs were not different in patients grouped according to their GFR. But, insulin resistance was higher in the group with BMI>25. CONCLUSION: A direct relationship between ADPKD and insulin resistance was not been shown in the study. The relationship between anthropometric measurements and insulin resistance in ADPKD patients is similar to the general population.