The Importance of Immunofl uorescence Staining in Patients with Primary FSGS

OBJECTIVE: In patients with primary FSGS, the degree of proteinuria, serum creatinine levels, histologic fi ndings, and response to therapy are important prognostic factors. In this study, the importance of immunofl uorescence staining on response to therapy and progression to chronic renal failure were retrospectively evaluated in patients with primary FSGS. MATERIAL and METHODS: Pathologic, clinical and laboratory features, follow-up outpatient/ clinical records of 60 patients with a pathologic diagnosis of FSGS by renal biopsy in GATA Nephrology Clinic between 2000-2012 were retrospectively evaluated. RESULTS: In this retrospective study conducted on the effect of the immunofl uorescence staining on renal surveillance in patients with primary FSGS, accumulation of fi brin was found to have a relationship with renal surveillance. Progression was more rapid in patients with fi brin accumulation, but this result did not reach a statistical signifi cance. No statistical relationship was found between other parameters and renal surveillance. For complete understanding of the possible negative impact of the accumulation of fi brin, further studies on larger patient groups are needed. CONCLUSION: The studies examining many parameters are in advance in order to estimate response to treatment in patients with primary FSGS. New parameters to predict renal surveillance is still needed while steroid or other immunosuppressives are been initiating in patients presenting with nephrotic range proteinuria.