CA 125 Elevation Due to Minimal Change Disease

Minimal change disease is a glomerular disease that can be primary or secondary and accounts for %10- 15 percent of adult nephrotic syndrome cases. Measurement of the serum concentration of the CA 125 glycoprotein antigen is the most widely used biochemical method of screening for ovarian cancer but the specificity of this method is limited. Mean CA 125 levels further vary with ethnicity and smoking status and increase with age. CA 125 levels are elevated in approximately 1 percent of healthy women and fluctuate during the menstrual cycle. Levels of CA 125 increase in a variety of conditions other than ovarian pathologies. In our case, we determined the reason of the approximately thirty times elevated CA 125 levels as the nephrotic syndrome We wanted to mention that even at these high levels, one should consider that the reason of the elevation of CA 125 may be nephrotic syndrome, not a malignant condition.