Renal Tissue and Plasma Oxidative Stress Status in Experimental Nephrotic Syndrome

In the present study, oxidative system status both in plasma and renal tissue of rats with adriamycin induced experimental rat nephrotic syndrome was investigated. Glutathion peroxidase (GSH-Px) activities and malondialdehyde (MDA) levels in plasma and MDA levels, GSH-Px and superoxide dismutase (SOD) activities in kidney homogenates were determined. Plasma MDA levels and tissue SOD activities were significantly higher in nephrotic rats when compared to those of the controls. No correlation was found between plasma and tissue MDA levels while plasma MDA levels of nephrotic rats had positively significant correlations with urinary protein excretion and serum total cholesterol levels. Serum albumin levels showed negatively significant correlations with plasma MDA levels in nephrotic rats. The data suggest that increased oxidative stress in renal tissue seem not to be responsible principally for high plasma MDA levels observed in rats with nephrotic syndrome. Nephrotic state has significant contributions to elevated plasma MDA levels and severity of nephrotic syndrome is related to the high levels of plasma MDA.