THE EFFECTS OF LOSARTAN AND ENALAPRIL ON URINARY ALBUMIN EXCREATION (UAE) IN TYPE H DIABETIC - MICRO ALBUMINURIC PATIENTS

Type II diabetic 32 patients (21 F, 11 M; aged 54 ±8 years) with mild-moderate hypertensive and persistent microalbuminuric were enrolled to the study. The diagnosis of diabetes had been done at least 5 years ago and the all patients were taking oral antidiabetic drugs. The patients using antihypertensive drugs during the last month were excluded from the study. The patients were fallen into two groups matched with age and weight. Losartan (50 mg/day) as an angiotensin receptor antagonist was given to the first group and enalapril (10 mg/day) was given to the second group with a duration of 6 months. UAE and BP levels were similar in both groups at the beginning. There were no significant changes in HbA\C, serum creatinine, uric acid and potassium levels during the treatment period. It was found that not only both drugs decreased blood pressure effectively, but they also decreased UAE significantly, while there was 60% decrease in UAE compared to the beginning values in the enalapril group, the rate of decrease in losartan group was 71 (%). UAE values decreased to the normoalbuminuric levels in more than half of the patient in both groups. But, we couldn't find any significant differences between two drugs interms of these effects.