CHRONIC RENAL FAILURE DUE TO HYPER OXALURIA IN PEDIATRIC PATIENTS

Primary hyperoxaluria is a rarely encountered disease characterised by recurrent urolithiasis, nephrocalcinosis, and oxalate deposition in almost all tissues, generally inherited in autosomal recessive fashion and the important complications of which can be prevented by early liver transplantation. Here we presented 3 boys with primary hyperoxaluria and early onset end stage renal failure aged 9, 10 and 14 years , in order to impress on the importance of early treatment. All the patients, treated for urolithiasis since their early childhood, had disturbed renal functions and anemia. Their renal ultrasonography revealed hyperechogenic kidneys and multiple stones. The urinary oxalate excretion of the three cases were all detected high (828 mmol/day, 500 mmol/day, 1390 mmol/day) and urinary citrate excretion low (52 mg/day, 50 mg/day and 124 mg/day). Together with the supportive treatment Pyridoxine and Potasium citrate were prescribed to the patients. The pateints receiving continuous renal replacement theapy have been followed up for 1-4 years.