OXIDATIVE -ANTI-OXIDATIVE SYSTEM IN PERIPARTUM ACUTE RENAL FAILURE AND PREECLAMPSIA -ECLAMPSIA

In this study we aimed to evaluate the oxidative -antioxidative systems in peripartum acute renal failure, preeclampsia -eclampsia. The study groups consisted of 17 patients with periparthum acute renal failure (8/17+HELLP Syndrome) (GI), 11 preeclamptic pregnant(GII), 11 pregnant (3 30 weeks) (Gill) and 11 healthy women (GIV) with aged 18-38 years. Superoxide dismutase (SOD), glutathione peroxidase (GSHPx) in erythrocytes and plasma malondialdehide (MDA) levels were measured in all groups. SOD, GSHPx and MDA levels were also measured at the beginning (GIA), regression of renal dysfunction (GIB) and recovery of renal functions (GIC). MDA levels were 11.95 ±4.25, 9.22±3.62, 5.10 ±3.65, 3.40 ± 1.27, 4.91 ± 2.06, 4.24 ± 1.67 mmol/ml in GIA, GIB, GIC, Gil, GUI and GIV respectively. SOD activitiy in erythrocyte were 3269.23+1437.83, 2641.35 ± 1411.13, 2056.35±l 143.11, 924.±160.04, 1057.91 ±257.03, 861.63+243.28 Ug/Hb in GIA, GIB, GIC, Gil, Gill and GIV respectively. GSHPx activity in erythrocyte were 70.17 ± 23.52, 58.27+23.75, 45.44+17.60, 24.48 + 6.77, 26.28 + 7.27, 32.95 ± 8.24 Ug/Hb in GIA, GIB, GIC, Gil, GUI and GIV respectively. MDA levels and activities of SOD, GSHPx in erythrocytes on the begining, improvement and recovery of acute renal failure (GIA, GIB and GIC) were significantly different from each other and their values decreased while regaining of renal functions. Preeclampsia-eclampsia or normal pregnancy did not cause elevation of plasma MDA levels and GSHPx, SOD in erythrocyte. Although SOD and GSHPx in erythrocytes and plasma MDA level were found similar in healthy women, pregnant women and preeclamptic women. In patients with peripartum acute renal failure SOD, GSHPx and MDA increased at the begining and decreased during recovery of renal functions.