ENDOTHELIAL AND VASCULAR DYSFUNCTION IN ESSENTIAL HYPERTENSION WITHOUT TARGET ORGAN DAMAGE

Disorders of the vessels, that cause organ demage in Essential Hypertension (HT), may returned at early stage. In this study, vascular disorders were evaluated in 225 HT patients with a mean age of 48.1±8.6 (%77.3 of them mild and moderate hypertensive) and in 114 healthy subjects with a mean age of 46.5±8.2 years. Their systolic and diastolic blood pressure (SBP and DBP) were found J60±14, 100±8 and 119±8, 78±5 mmHg. In HT group, body mass index (BMI), fasting blood sugar (FBS), fibrinogen, von Willebrand Factor, activated platelet aggregation with adenosine diphosphate and epinephrine, lipoprotein (a)-(Lp(a)), triglyceride (TG), Uric acid (UA) values were found to be higher than those in control group. Hypertensive retinopathy was observed in the 58 % of the patients. In healthy controls SBP, DBP, and in both groups Hb, serum creatinin, TG, UA values of the males were found to be higher than those in female groups. Age and BMI were not significant different between the groups. Hb, UA, TG, Lp(a) were found higher in smokers than those in nonsmokers, in the patients group. Pozitive correlation between vascular markers and blood pressure, age of patient, duration, smoking and between FBS and obesity were observed. Serum Nα* value was decreased with diatery Na+ restriction. Our findings suggest that vascular changes occur at early stage ofHT, especially male gender, smokers have high risk and obesity has additional effect for its.