CHRONIC LYMPHOCYTIC LEUKEMIA ASSOCIATED WITH NEPHROTIC SYNDROME

Chronic Lymphocytic Leukemia (CLL) is a hematologic neoplasm characterized by the accumulation mature-appearing lymphocytes in the peripheral blood associated with infiltration of the bone marrow, spleen, lymph nodes and occasionally other organs. Glomerulopathy is a rare complication of CLL The most common clinical presentation of CLLassociated glomerulopathy is the nephrotic syndrome. A 72- year-old woman developed nephrotic syndrome four years after diagnosed Rai Stage- O CLL. Percutaneous renal biopsy showed characteristic features of membranoproliferative glomerulonephritis. At this stage of CLL, treatment with alkylating agents was not recommended. So, we didn't use alkylating agents in our patient. Supportive measures with diuretics, essential aminoacids with ketoanalogues, dipyridamole, acetly salicylic acid were undertaken. Available evidence suggests that nephrotic syndrome associated with CLL is not fortuitous and often related to immun-complex disease.