VARIATIONS OF SERUM APOLIPOPROTEIN LEVELS IN MINIMAL LESION NEPHROTIC SYNDROME

Variations in plasma lipids and lipoprotein levels were evaluated during the course of the nephrotic syndrome in 20 children (17 males, 3 females, aged 1,5-13 years). Of these ten were in relapse, ten were in remission. Results were compared to those obtained in a control population of 30 age-matched children. Serum apoprotein A1 (apo A1) levels were increased in children with relapsing nephrotic syndrome compared to controls (mean value of 131.863 mg/dl 5 vs. 11.220 mg/dl) but remained within the normal ranges (115-190 mg/dl). Of the patients in relapse apoprotein B (apo B) levels were measured as higher during the acute phase of the disease (284.7±93.4 mg/dl) and the lowest in remission (79.7±22.2 mg/dl) (p<0.05) compared with controls (92.1±27). The difference between apo B levels in remission and control groups was not statistically different.