IMMUNE RESPONSE TO DIFFERENT DOSE RECOMBINANT HEPATITIS B VACCINE IN HEMODIALYSIS PATIENTS

Hepatitis B vaccine is recommended different dosage and different way from the allot of study in hemodialysis patients. We aim to investigate the effect of single and double dose hepatitis B vaccine in hemodialysis patients. In this study there was 56 HD patients. Patients were divided into groups. There was 36 patients in the first and 20 patients in the second group. Patients were dialysed twice or three times weekly 4 hours with poly-sulphane membrane. 20 μgr dose of vaccine at 0, 1 and 6th months were given intramuscularly (IM) in the first group. 40 mgr dose of vaccine at the same time and route in the second group. AntiHBs levels were measured before dialysis at 1,2 and 7 th months. Anti-HBs 10 > WI ml was accepted as a protective level using for hepatitis B virus infection. The data were analysed the APPS computer statistic programme with chi-square test, Student's t test. The level of anti-HBs was greater than 10 IU/ml 69 percent in first group, 85 percent in the second group at end of the seventh month. In the second group level of antiHBs was higher than the first group and was significant statistically (p<0.05). In conclusion, we that recommended double dose hepatitis B vaccine in hemodialysis patients.