EFFECT OF BROMOCRIPTINE THERAPY ON GONADAL FUNCTIONS AND PROLACTIN LEVELS IN MALE PATIENTS ON CHRONIC HEMODIALYSIS

Blood levels of FSH, LH, E2 , T and PRL hormones were studied in 30 male patients with chronic renal failure (CRF) on chronic hemodialysis treatment. FSH, LH, Ei and PRL levels of these 30 male patients were statistically significantly higher (p<0.001) than the levels of the control group, where as the T levels were significantly lower (p<0.001). After intramuscular administration of 50 mg parlodel to these 30 male patients, hormone levels were measured on the 1st, 7th, 15th, 30th, 45th days of injection. There were no significant difference between the pre and post treatment values of FSH, LH and E2 (p>0.05), but the decrease in PRL level with in the first 15 days after the treatment was found to be statistically significant (p<0.001). Statistically significant elevation of T hormone levels were also detected from the 7th day of treatment (p<0.01). Besides experiencing an increase in libido and sexual functions, most of the patients stated their satisfaction with their sexual activities. As a conclusion, we believe that treatment with bromocryptine is likely to be successful in the treatment of sexual dysfunction in male patients with CRF on chronic hemodialysis treatment.