Comparing Teriparatide and Bisphosphonates for Postmenopausal Osteoporosis: A Systematic Review and Meta‐Analysis of RCTs

ABSTRACT Introduction Osteoporosis is a bone disorder highly prevalent in post‐menopausal women and is an important predisposing factor towards bone fractures. It is commonly classified based on BMD, which is estimated via DEXA scan. It is an important issue worldwide and requires a multidisciplinary approach to be controlled. Methods Utilizing online sources including PubMed, Embase, Cochrane, and Google Scholar, a thorough literature search was conducted. To determine the best treatment options with fewer difficulties and adverse events and more good results. There were discovered to be 15 RCTS that qualified. The study was carried out per PRISMA recommendations. Results According to the outcomes generated from the study, there was a significantly reduced rate of overall vertebral and non‐vertebral fractures with teriparatide use along with data supporting increased BMD observed in the teriparatide group. Importantly, there was a reduction in death rate too observed in the intervention group. The results were also consistent with our various secondary outcomes. Conclusion We can conclude from the outcomes that a clinically significant result was generated in the group using teriparatide in various aspects. There were still some confounding factors present that need to be addressed to increase the yield of the study, and with increasing research in the field, more comprehensive studies are required in the future to reach a definitive outcome.