Integration of Continuous Glucose Monitoring With HbA1c to Improve the Detection of Prediabetes in Asian Individuals: Model Development Study

Abstract BackgroundGlycated hemoglobin (HbA1c ObjectiveExploiting the glycemic variability captured in continuous glucose monitoring (CGM), we used a well-characterized Asian cohort study from Singapore to assess whether utilizing CGM features in a machine learning model can improve the detection of prediabetes as compared to using HbA1c MethodsIn this study, 406 nondiabetic Asian participants underwent an oral glucose tolerance test and had their fasting and 2-hour plasma glucose concentrations measured, together with HbA1c1c ResultsIn this cohort (N=406), 189 (46.6%) individuals had prediabetes. The majority of the cohort were women (n=236, 58.1%) and of Chinese ethnicity (n=267, 65.8%). Those with prediabetes were slightly older, heavier, and had higher glucose levels with more variability than the normoglycemia group. A 2-step approach was used where those with HbA1c1c1c ConclusionsAdding CGM to HbA1c