TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

ABSTRACT Exosomes serve as intercellular communication vectors and are involved in a broad range of physiological functions. Although exosome‐based therapies have demonstrated diverse functional potential, the regulatory mechanisms underlying their biogenesis and secretion remain poorly understood. Here, we report that TEAD1 functions as a molecular switch, dramatically enhancing the synthesis and secretion of exosomes. Mechanistically, TEAD1 enhances exosome secretion by promoting the expression of exosome secretion‐associated proteins RAB11, CD9, and SNAP23. We found that TEAD1 enhances exosome secretion from adipose‐derived mesenchymal stem cells, thereby promoting skin wound healing in diabetic mice. Similarly, TEAD1 promotes the release of exosomes from bone marrow‐derived mesenchymal stem cells, thereby facilitating spinal cord injury (SCI) repair. Our study elucidates a novel role for TEAD1 in driving exosome secretion in different cell types, highlighting the therapeutic potential of TEAD1 in enhancing tissue regeneration, particularly in diabetic wound healing and SCI repair.