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Multicenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress

Popat Vinita et al · De Gruyter · 2025

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Autore / responsabile
Popat Vinita et al
Editore
De Gruyter
Anno
2025
ISSN
2364-7671
ISSN
2364-7671
Lingua
Inglés

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Ovarian cancer (OC) often presents with peritoneal metastases (PM) which contribute significantly to morbidity and treatment resistance. Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) has emerged as a promising modality for locoregional drug delivery in peritoneal surface malignancies. Historically, combined intraperitoneal (IP) and intravenous (IV) cisplatin and paclitaxel regimens have demonstrated activity in first-line OC treatment. PIPAC nab-paclitaxel and cisplatin with systemic nab-paclitaxel holds promise as a safe and effective therapy, but has not been explored in OC.

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APA 7

al, P. V. E. (2025). Multicenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress. https://doi.org/10.1515/pp-2025-0036

MLA

al, Popat Vinita et. "Multicenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress." 2025. https://doi.org/10.1515/pp-2025-0036.

Chicago

al, Popat Vinita et. 2025. "Multicenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress.". https://doi.org/10.1515/pp-2025-0036.

Harvard

al, P. V. E. 2025, Multicenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress, De Gruyter, available at: https://doi.org/10.1515/pp-2025-0036 [Accessed 7 Aug. 2026].

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Titolo
Multicenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress
Autore / collaboratori
Popat Vinita et al
Editore
De Gruyter
Anno di pubblicazione
2025
ISSN
2364-7671
ISSN
2364-7671
Lingua
Inglés

Soggetti

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ovarian cancer; phase i trial; pipac; nab-paclitaxel; multimodal therapy
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