Platelets and platelet-derived factors in curcumin treatment: a narrative review of mechanisms and translational potential

Based on the characteristics of curcumin, such as low bioavailability, low toxicity, wide availability, and multiple biological activities, and in conjunction with its established pharmacological effects on anti-platelet activation, aggregation inhibition, and platelet count enhancement, the following hypothesis is proposed: Curcumin may exert therapeutic effects in multiple systems, including cardiovascular, neurological, digestive, musculoskeletal, and genitourinary systems, by modulating platelet function and its derived factors, thereby interfering with various disease-related pathways. In light of this, the present study aims to address the following questions: Through which specific molecular pathways and mechanisms does curcumin regulate platelets and their derived factors, thereby exerting therapeutic effects on diseases in different systems? Additionally, this research seeks to provide a theoretical foundation for further exploration of novel therapeutic directions for curcumin in disease treatment.