Staphylococcal Gangrenous Cholecystitis: A Case Report

Gangrenous cholecystitis is a severe and potentially fatal complication of acute cholecystitis, typically resulting from ischemic necrosis of the gallbladder wall secondary to sustained obstruction and inflammation. We present a rare case of methicillin-sensitive Staphylococcus aureus–associated gangrenous cholecystitis with bacteremia in an elderly female without identifiable risk factors for staphylococcal infection. The patient was treated with antibiotics and emergent percutaneous cholecystostomy. This case highlights the need to consider infrequent pathogens, such as S. aureus, in patients with severe cholecystitis, particularly when clinical deterioration persists despite standard empirical therapy. Early diagnosis and prompt multidisciplinary management remain the key to a favorable outcome in this medically complex patient.