Revitalizing the “biology” in “chronobiology”

Abstract Studies of biological timekeeping have now matured from investigations of a fascinating and ubiquitous phenomenon into a discipline with practical applications; the excitement surrounding such translation has been overwhelming, perhaps at the expense of eclipsing further pursuit of basic research. Here we advocate that the ultimate success of applying chronobiological principles to address human and environmental needs will depend on the continued support of a robust agenda of fundamental research.