Portable AI-powered scanning slit-light device for low-cost eye disease screening

Abstract Accurate anterior-segment assessment is essential for detecting conditions such as primary angle-closure glaucoma, cataract, and keratoconus, yet current tools remain limited: slit-lamp biomicroscopy is qualitative and operator-dependent, whereas anterior segment OCT (AS-OCT) is costly and clinic-bound. We introduce an AI-integrated portable scanning slit-light device that delivers quantitative anterior-segment biometry at a material cost below USD 500. The system combines a motorized slit-scanning mechanism with synchronized imaging and an on-device deep-learning model (LWBNA-unet) to segment corneal and iris reflections, pupil boundaries, and corneal surfaces. Geometry-aware corrections—including slit-incidence compensation and per-frame anatomical scaling—enable calibrated estimation of anterior chamber depth (ACD) as the primary quantitative output, with exploratory estimates of central corneal thickness (CCT) derived from the same scan. In a clinical study of 170 participants, ACD showed excellent agreement with AS-OCT (Pearson’s r ≈ 0.92, concordance correlation coefficient ≈ 0.90; mean bias ≈ 0.0–0.04 mm with 95% limits of agreement LoR ~ ± 0.3 mm) indicating near-clinical interchangeability for ACD in a screening context. Representative cases illustrated clear visualization of anterior-segment features associated with narrow angles, cataract, corneal opacity, and keratoconic ectasia from a single scanning-slit video. A typical 51-frame video (captured in ~ 15 s) can be fully processed on a Jetson Orin Nano in 18.5 s (≈ 2.7 fps), supporting compact, battery-powered deployment. These results establish the first ultra–low-cost platform capable of automated, quantitative, and anatomically calibrated anterior-segment imaging, offering a scalable foundation for community screening and teleophthalmology in resource-limited settings.