Effect of the aqueous extract and some proteinous compounds from Aleo vera leaves on Blood serum glucose and cholesterol levels in normal mice

Abstract Two proteinous compounds (I and II) had been isolated by gel filtration chromatography of the precipitate produced by full saturation of the aqueous extract of the Aloe vera. The apparent molecular weights by gel filtration chromatography of the isolated compounds (I and II) were in the range of (63095,19952) Dalton respectively. The effect of the aqueous extract and the proteinous fractions on glucose and cholesterol levels in normal mice were investigated. Glucose level was lowered by intraperitoneally administration of the concentrated aqueous extract and the low molecular weight proteinous compound (II) by (41.77% and 36.71%) respectively in normal mice. Furthermore, there was non significant reduction in the cholesterol levels by intraperitoneally administration of high molecular weight proteinous compound (Peak I) by (19.98%) in normal mice. Also there was non significant reduction in the glucose levels by orally administration of (40 mg/10 ml) of low molecular weight proteinous compound (Peak II) by (15.56%).