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Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films

Pattnaik, Satyanarayan et al · SEDICI UNLP · 2009

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Autor / responsable
Pattnaik, Satyanarayan et al
Editorial
SEDICI UNLP
Año
2009
Idioma
en

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In the present study, the influence of polymeric concentration, its blend and drug loading dose on the in vitro drug release pattern of alfuzosin hydrochloride from its transdermal patches has been investigated. Ratio of EC and PVP and drug loading dose were selected as independent variables and their influence on the percentage drug released at 24 h (Q24), drug release rate (KH) and time taken for 50% drug release (t50%) were studied using statistical experimental designing. Ratio of EC and PVP was found to be the main influential factor for all the dependent variables studied. Drug loading dose was also found to influence the dependent variables but to a lesser extent. Physicochemical parameters of the prepared patches were also evaluated. This study could be used as a screening method for further development of transdermal delivery of alfuzosin hydrochloride and skin permeation studies. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Pattnaik, S. E. A. (2009). Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films. http://sedici.unlp.edu.ar/handle/10915/7726

MLA

Pattnaik, Satyanarayan et al. "Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films." 2009. http://sedici.unlp.edu.ar/handle/10915/7726.

Chicago

Pattnaik, Satyanarayan et al. 2009. "Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films.". http://sedici.unlp.edu.ar/handle/10915/7726.

Harvard

Pattnaik, S. E. A. 2009, Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/7726 [Accessed 30 Jun. 2026].

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Título
Influence of Polymeric System and Loading Dose on Drug Release from Alfuzosin Hydrochloride Transdermal Films
Autor / colaboradores
Pattnaik, Satyanarayan et al
Editorial
SEDICI UNLP
Año de publicación
2009
Idioma
en

Materias

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Farmacia; alfuzosin hydrochloride; drug release; FT IR; polymeric system; SEM; Transdermal delivery; Medicamento; Evaluación de drogas
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