Comparative study on the pharmacokinetics of Ginkgo biloba extract between normal and diabetic rats by HPLC-DAD

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Comparative study on the pharmacokinetics of Ginkgo biloba extract between normal and diabetic rats by HPLC-DAD

Tang, Daoquan et al · SEDICI UNLP · 2009

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Tang, Daoquan et al

Editorial

SEDICI UNLP

Año

2009

Idioma

en

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A new HPLC-DAD method has been developed and validated for the simultaneous analysis of five flavonoids (rutin, quercitrin, quercetin, kaempferol, and isorahamnetin) in rat plasma. Sample pretreatment consisted of a liquid–liquid extraction. The five flavonoids was separated on a kromasil C18 column and recorded at 350 nm. The greatest resolution was achieved with methanol-0.1% formic acid gradient at a flow rate of 1.0 mL min<sup>-1</sup> (The correlation coefficients for all the calibration plots (r > 0.999 . showed good linearity over the range tested. The relative standard deviation of the method was less than 7% and 10% for intra and inter-day assays respectively, and average recovery was between 77.2 and 99.2%. The detection limits of this method were between 0.006 and 0.02 μg mL<sup>-1</sup> The method has been . successfully applied to determine drug concentrations in normal and diabetic rat plasma samples and pharmacokinetic of Ginkgo biloba extract Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Tang, D. E. A. (2009). Comparative study on the pharmacokinetics of Ginkgo biloba extract between normal and diabetic rats by HPLC-DAD. http://sedici.unlp.edu.ar/handle/10915/7775

MLA

Tang, Daoquan et al. "Comparative study on the pharmacokinetics of Ginkgo biloba extract between normal and diabetic rats by HPLC-DAD." 2009. http://sedici.unlp.edu.ar/handle/10915/7775.

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Tang, Daoquan et al. 2009. "Comparative study on the pharmacokinetics of Ginkgo biloba extract between normal and diabetic rats by HPLC-DAD.". http://sedici.unlp.edu.ar/handle/10915/7775.

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Tang, D. E. A. 2009, Comparative study on the pharmacokinetics of Ginkgo biloba extract between normal and diabetic rats by HPLC-DAD, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/7775 [Accessed 29 Jun. 2026].

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Título: Comparative study on the pharmacokinetics of Ginkgo biloba extract between normal and diabetic rats by HPLC-DAD

Autor / colaboradores: Tang, Daoquan et al

Editorial: SEDICI UNLP

Año de publicación: 2009

Idioma: en

Materias

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Farmacia; Plantas medicinales; ginkgo biloba extract; high performance liquid chromatography; isorhamnetin; kaempferol; quercitrin; pharmacokinetic; quercetin; rutin; Extractos de plantas; Cromatografia líquida de alta eficiencia; Farmacocinética