Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study

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Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study

Oliveira, Bérgson F. et al · SEDICI UNLP · 2009

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Autor / responsable

Oliveira, Bérgson F. et al

Editorial

SEDICI UNLP

Año

2009

Idioma

en

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W/O/W multiple emulsions containing naltrexone (NTX) hydrochloride were prepared by a two-step emulsification method at 20 ºC. Characterization of the developed system was evaluated and the release kinetics of the drug was determined. The tissue response to the injection of the multiple emulsion in mice was observed by histological analysis. The entrapment efficiency of NTX hydrochloride in W/O/W multiple emulsion was 97.72 ± 0.8 % and the mean diameter of the multiple globules was 18.6 ± 7.7 μm. The main in vitro drug release mechanism observed for the developed system is supposed to be a swellingbreakdown phenomenon after dilution of the emulsions under hypo-osmotic conditions. Biocompatibility studies showed that the multiple emulsion was well tolerated as no significant toxic reaction was observed. The W/O/W multiple emulsion containing NTX hydrochloride may represent a potential alternative dosage form for the treatment of alcohol dependence. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Oliveira, B. F. E. A. (2009). Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study. http://sedici.unlp.edu.ar/handle/10915/7776

MLA

Oliveira, Bérgson F. et al. "Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study." 2009. http://sedici.unlp.edu.ar/handle/10915/7776.

Chicago

Oliveira, Bérgson F. et al. 2009. "Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study.". http://sedici.unlp.edu.ar/handle/10915/7776.

Harvard

Oliveira, B. F. E. A. 2009, Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/7776 [Accessed 29 Jun. 2026].

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Título: Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study

Autor / colaboradores: Oliveira, Bérgson F. et al

Editorial: SEDICI UNLP

Año de publicación: 2009

Idioma: en

Materias

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Farmacia; alcohol dependence; drug delivery system; naltrexone hydrochloride; W/O/W multiple emulsion; Alcoholismo; Evaluación de drogas; Productos químicos y drogas