Structure-activity relationship study of twelve compounds from Paris polyphylla Smith var. pubescens

Twelve compounds were isolated from the rhizoma of Paris polyphylla Smith var. pubescens Handel-Mazzetti. Based on spectral data, the isolated compounds were identified as stigmasterol (1), β- Ecdysterone (2), Diosgenin (3), Ophiopogonin C’ (4), Diosgenin-3-O-α-L-arabinofuranosyl(1→4)-β-D-glucoside (5), Dioscin (6), Paris saponin I (7), Paris saponin II (8), Pennogenin-3-O-α-L- arabinofuranosyl (1→4)- β- D-glucoside (9), Paris saponin VI (10), Pennogennin- 3-O-α-L-arabinofuranosyl(1→4)-[α-Lrhamnopyranosyl(1→2)]-β-D-glucoside (11) and Paris saponin VII (12). Their cytotoxicity and anti-migration on mouse B16 melanoma cells were evaluated. Colegio de Farmacéuticos de la Provincia de Buenos Aires