Fast dispersible tablet of paroxetine hydrochloride: taste masking and administration in depressed patients

The bitter taste of paroxetine hydrochloride was masked by complexation with beta cyclodextrin. Complexation of paroxetine hydrochloride with beta cyclodextrin was characterized by differential scanning calorimetry and X-ray powder diffraction. The taste masked complex was directly compressed into tablets using povidone Cl as a super-disintegrant along with other excipients which aid in further improvement of taste. The prepared tablets containing the taste masked complex were evaluated for taste by both in vitro release profile and through panel testing. The taste masked tablets were administered to actual patients by mixing with juices to study weather the patients identifies the presence of medicine in the juices. The results of this study were satisfactory. Colegio de Farmacéuticos de la Provincia de Buenos Aires