Determination of dextromethorphan in rabbit plasma by LC-MS/MS and its application to pharmacokinetic study

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Determination of dextromethorphan in rabbit plasma by LC-MS/MS and its application to pharmacokinetic study

Hu, Lufeng et al · SEDICI UNLP · 2010

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Hu, Lufeng et al

Editorial

SEDICI UNLP

Año

2010

Idioma

en

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A highly sensitive liquid chromatographic tandem mass spectrometric (LC-MS/MS) method for determination of dextromethorphan in rabbit plasma using triazolam as the internal standard (IS) was developed. Plasma samples were extracted with ethyl acetate and separated on a SB-C18 column with a mobile phase of acetonitrile-water 60:40 (v/v) at a flow of 0.3 mL/min. Detection is carried out by multiple reaction monitoring (MRM) on a ion-trap LC-MS/MS system with an electrospray ionization interface. The lower limit of quantification (LLOQ) was 1 ng/mL. After intravenous administration of a single dose of dextromethorphan 2 mg/kg, the main pharmacokinetic parameters were as follows: AUC<sub>0→t</sub> 636.13 ± 47.13 (ng/mL·h); CL 2.60 ± 0.24 (L/h), C<sub>max</sub> 874 ± 67.16 (ng/mL), Vz 1.58 ± 0.11 (L/kg), T1/2 2.41 ± 0.35 (h), MRT 1.26 ± 0.08 (h). Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Hu, L. E. A. (2010). Determination of dextromethorphan in rabbit plasma by LC-MS/MS and its application to pharmacokinetic study. http://sedici.unlp.edu.ar/handle/10915/7994

MLA

Hu, Lufeng et al. "Determination of dextromethorphan in rabbit plasma by LC-MS/MS and its application to pharmacokinetic study." 2010. http://sedici.unlp.edu.ar/handle/10915/7994.

Chicago

Hu, Lufeng et al. 2010. "Determination of dextromethorphan in rabbit plasma by LC-MS/MS and its application to pharmacokinetic study.". http://sedici.unlp.edu.ar/handle/10915/7994.

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Hu, L. E. A. 2010, Determination of dextromethorphan in rabbit plasma by LC-MS/MS and its application to pharmacokinetic study, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/7994 [Accessed 30 Jun. 2026].

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Título: Determination of dextromethorphan in rabbit plasma by LC-MS/MS and its application to pharmacokinetic study

Autor / colaboradores: Hu, Lufeng et al

Editorial: SEDICI UNLP

Año de publicación: 2010

Idioma: en

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Farmacia; dextromethorphan; LC-MS/MS; determination; rabbit; pharmacokinetic; Medicamentos; Farmacología; Farmacocinética