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In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice

Xuming, Deng et al · SEDICI UNLP · 2011

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Autore / responsabile
Xuming, Deng et al
Editore
SEDICI UNLP
Anno
2011
Lingua
Español

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Extracts from Ledum palustre (LP) have shown many benefit activities, while, the toxicity of extracts from LP was seldom reported. In the present study, we evaluated the genotoxicity of crude extract from LP. Our results demonstrated that the maximal tolerance dose (MTD) of LP extract was more than 30 g/kg BW in mice (oral). LP extract at doses of 2.5, 5.0 and 10.0 g/kg BW had no genotoxicity in mice and could inhibit cyclophosphamide (CP), a well known anti-tumor drug, induced genotoxicity in mice. LP extract at concentrations of 0.05 g/mL, 0.005 g/mL, and 0.0005 g/ mL had scavenging activity on O2-·in a dose-related way. It was concluded that LP extract had protective effects on CP induced genotoxicity in mice and the protective mechanism of LP extract appeared to be related to antioxidant activity. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Xuming, D. E. A. (2011). In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice. http://sedici.unlp.edu.ar/handle/10915/8109

MLA

Xuming, Deng et al. "In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice." 2011. http://sedici.unlp.edu.ar/handle/10915/8109.

Chicago

Xuming, Deng et al. 2011. "In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice.". http://sedici.unlp.edu.ar/handle/10915/8109.

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Xuming, D. E. A. 2011, In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8109 [Accessed 8 Aug. 2026].

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Titolo
In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice
Autore / collaboratori
Xuming, Deng et al
Editore
SEDICI UNLP
Anno di pubblicazione
2011
Lingua
Español

Soggetti

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Farmacia; Extractos Vegetales; acute toxicity; antioxidant activity; chromosome aberration test; Ledum palustre; micronucleus test; sperm morphology test; Genotoxicidad; Ciclofosfamida
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