Pharmacological basis for the medicinal use of Valeriana wallichii in constipation

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Pharmacological basis for the medicinal use of Valeriana wallichii in constipation

Khan, Arif-ullah et al · SEDICI UNLP · 2011

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Khan, Arif-ullah et al

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SEDICI UNLP

Anno

2011

Lingua

Inglés

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Valeriana wallichii D.C. (Valerianaceae) is widely used in folk medicine for the treatment of hypo-motility disorder of the gut. The aim of the present study was to scientifically rationalize its usefulness in the constipation. The V. wallichii leaves crude extract, which tested positive for the presence of anthraquinones, flavonoids, saponins, sterols, tannins and terpenes caused concentration-dependent (3-10 mg/mL) contractile effect in isolated guinea-pig ileum. Pretreatment of tissues with atropine (1 μM) completely abolished the stimulatory effect of V. wallichii leaves crude extract, similar to that of acetylcholine. These results indicate that the spasmogenic effect of V. wallichii is mediated possibly through the activation of muscarinic receptors, which provides sound mechanistic background for its medicinal use in constipation. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Khan, A. U. E. A. (2011). Pharmacological basis for the medicinal use of Valeriana wallichii in constipation. http://sedici.unlp.edu.ar/handle/10915/8121

MLA

Khan, Arif-ullah et al. "Pharmacological basis for the medicinal use of Valeriana wallichii in constipation." 2011. http://sedici.unlp.edu.ar/handle/10915/8121.

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Khan, Arif-ullah et al. 2011. "Pharmacological basis for the medicinal use of Valeriana wallichii in constipation.". http://sedici.unlp.edu.ar/handle/10915/8121.

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Khan, A. U. E. A. 2011, Pharmacological basis for the medicinal use of Valeriana wallichii in constipation, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8121 [Accessed 8 Aug. 2026].

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Titolo: Pharmacological basis for the medicinal use of Valeriana wallichii in constipation

Autore / collaboratori: Khan, Arif-ullah et al

Editore: SEDICI UNLP

Anno di pubblicazione: 2011

Lingua: Inglés

Soggetti

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Farmacia; cholinergic; constipation; spasmogenic; Valeriana wallichii; Receptores Muscarínicos; Valeriana; Estreñimiento; Extractos Vegetales