In vitro/in vivo assessment of flurbiprofen-matrix type transdermal delivery system
Aamir, Muhammad F. et al · SEDICI UNLP · 2011
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enhancers [isopropyl myristate (IPM), isopropyl palmitate (IPP) and Tween 80] were formulated, evaluated
and compared. The cumulative amounts permeated and the permeation rates were higher for the prepared
formulations as compared to the controls (without enhancers). The results also revealed better skin
permeation characteristics of flurbiprofen using IPM than other enhancers. The pharmacokinetic parameters
of the optimized formulation (F7), calculated from the blood levels of the drug, revealed a profile
with the ability to maintain adequate plasma levels for 24 h (i.e. up to the next application): AUC<sub>(0-24)</sub>
10.406 ± 1.34ng.h/ml, T<sub>max</sub> 1.5 ± 0.91 and C<sub>max</sub> 1.3049 ± 0.21 µg.ml<sup>-1</sup>-. The amount of drug bioavailable for
targeting the site of action is comparable to that of market control. Based on experimental results, preparation
of 10 % flurbiprofen matrix type patch formulation containing IPM is promising
Colegio de Farmacéuticos de la Provincia de Buenos Aires
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APA 7
Aamir, M. F. E. A. (2011). In vitro/in vivo assessment of flurbiprofen-matrix type transdermal delivery system. http://sedici.unlp.edu.ar/handle/10915/8139
MLA
Aamir, Muhammad F. et al. "In vitro/in vivo assessment of flurbiprofen-matrix type transdermal delivery system." 2011. http://sedici.unlp.edu.ar/handle/10915/8139.
Chicago
Aamir, Muhammad F. et al. 2011. "In vitro/in vivo assessment of flurbiprofen-matrix type transdermal delivery system.". http://sedici.unlp.edu.ar/handle/10915/8139.
Harvard
Aamir, M. F. E. A. 2011, In vitro/in vivo assessment of flurbiprofen-matrix type transdermal delivery system, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8139 [Accessed 28 Jun. 2026].
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- Título
- In vitro/in vivo assessment of flurbiprofen-matrix type transdermal delivery system
- Autor / colaboradores
- Aamir, Muhammad F. et al
- Editorial
- SEDICI UNLP
- Año de publicación
- 2011
- Idioma
- en
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