Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia)
Márquez, Diana M. et al · SEDICI UNLP · 2011
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in the Urabá Gulf (Colombia) were tested against three human tumor cellular lines, including lung (A-
549), colon (HT29) and breast (MDA-MB-231), at 1 µg/mL, 5 µg/mL and 25 µg/mL. The most bioactive extract
(ethanol), was separated by flash column chromatography obtaining six fractions which biological
activity was evaluated on the same cellular lines A-549, HT29 and MDA-MB-231, at 1µg/mL, 5 µg/mL and
25 µg/mL. The bioassay results showed that both extracts and two of the fractions totally inhibited the
growing of the cellular line A549 at 25 µg/mL, while the most active fraction showed total inhibition of the
growing of the three tumor cell lines on the three evaluated concentrations. The most active fraction was
separated by reversed phase HPLC which allowed isolating and then characterizing by mono- and bidimensional
NMR, a halogenated compound derived from the bromotyrosine.
Colegio de Farmacéuticos de la Provincia de Buenos Aires
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APA 7
Márquez, D. M. E. A. (2011). Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia). http://sedici.unlp.edu.ar/handle/10915/8152
MLA
Márquez, Diana M. et al. "Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia)." 2011. http://sedici.unlp.edu.ar/handle/10915/8152.
Chicago
Márquez, Diana M. et al. 2011. "Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia).". http://sedici.unlp.edu.ar/handle/10915/8152.
Harvard
Márquez, D. M. E. A. 2011, Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia), SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8152 [Accessed 24 Jun. 2026].
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- Título
- Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Urabá Gulf (Colombia)
- Autor / colaboradores
- Márquez, Diana M. et al
- Editorial
- SEDICI UNLP
- Año de publicación
- 2011
- Idioma
- en
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