Synthesis, anti-inflammatory and analgesic activity of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1,2,4-triazole derivatives

A novel series of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1, 2, 4-triazole derivatives were synthesized by reaction of 5-substituted phenyl-3,4-diamino-1,2,4-triazole with different aromatic aldehydes. The structures of the compounds were synthesized and characterised by elemental analysis, 1H NMR, Mass and IR Spectra. The title compounds were investigated for anti-inflammatory and analgesic activities using carrageenan induced rat paw edema and acetic induced writhing test, respectively. All the test compounds exhibited significant activity, compounds IVg, IVh and IVb showed more potent anti-inflammatory activity when compared with standard (Ibuprofen). All the test compounds were significantly (p < 0.05) reduced writhings induced by the acetic acid in mice. Colegio de Farmacéuticos de la Provincia de Buenos Aires