Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol

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Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol

Rao, Monica et al · SEDICI UNLP · 2011

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Autore / responsabile

Rao, Monica et al

Editore

SEDICI UNLP

Anno

2011

Lingua

Inglés

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The objective of the work was to develop, optimize and evaluate self-microemulsifying drug delivery system (SMEDDS) of carvedilol (CDL), a poorly water-soluble drug. SMEDDS was developed to increase the solubility, dissolution rate and ultimately, oral bioavailability of CDL. The solubility of CDL was determined in various oils, surfactants and cosolvents. Pseudoternary phase diagrams were used to identify the region of microemulsification. The SMEDDS were characterized by morphological observation, droplet size and zeta-potential, cloud point, % transmission study and emulsification time. The optimized formulation was composed of Capmul MCM C8 (18 %), Tween 80 (65.6 %), and polyethylene glycol 400 (14.4 %). The SMEDDS formulation showed complete release in 20 min as compared with the plain drug, which showed a limited dissolution rate. Colegio de Farmacéuticos de la Provincia de Buenos Aires

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APA 7

Rao, M. E. A. (2011). Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol. http://sedici.unlp.edu.ar/handle/10915/8225

MLA

Rao, Monica et al. "Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol." 2011. http://sedici.unlp.edu.ar/handle/10915/8225.

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Rao, Monica et al. 2011. "Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol.". http://sedici.unlp.edu.ar/handle/10915/8225.

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Rao, M. E. A. 2011, Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol, SEDICI UNLP, available at: http://sedici.unlp.edu.ar/handle/10915/8225 [Accessed 10 Aug. 2026].

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Titolo: Preparation and evaluation of self-microemulsifying drug delivery system of carvedilol

Autore / collaboratori: Rao, Monica et al

Editore: SEDICI UNLP

Anno di pubblicazione: 2011

Lingua: Inglés

Soggetti

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Farmacia; carvedilol; polyethylene glycol 400; capmul MCM C8; Sistemas de Liberación de Medicamentos; Formas de Dosificación