Comparative hemodynamic effects between AVM and HFO: implications in veterinary clinical practice

ABSTRACT High-frequency oscillatory ventilation (HFO) is a mechanical ventilation technique used in veterinary medicine to treat various respiratory diseases, particularly in small animal patients, but its potential application in critical care settings and its effects on cardiopulmonary function remain insufficiently explored. This study compared HFO and conventional mechanical ventilation (CMV) in neonatal piglets, assessing systemic and regional oxygenation and ventilatory parameters. HFO resulted in significantly higher maximal inspiratory pressure (MIP) (23.9±4.4 vs 18.6±0.9, p<0.001) and mean airway pressure (MAP) (8.8±1.6 vs 6.1±0.2) than CMV. Mean arterial pressure was significantly lower in the HFO group. After 60 minutes, regional renal fossa tissue oxygenation (rNIRS) was significantly higher in the CMV group (114.23±13.03 vs. 99.31±10.7, p<0.05), whereas no significant difference was observed in cerebral NIRS (cNIRS). Blood gas analysis showed no significant differences between groups. While HFO demonstrated different ventilatory mechanics in this piglet model, the comparable gas exchange suggests it warrants further investigation as a potential ventilation strategy in veterinary patients.