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In Silico Structural Analysis of The Cell Division Protein, FtsZ: Screening Natural Products for Inhibitors

mohammed saeed et al · University of Mosul, College of Education for Pure Science · 2019

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Autore / responsabile
mohammed saeed et al
Editore
University of Mosul, College of Education for Pure Science
Anno
2019
ISSN
1812-125X
ISSN
1812-125X
Lingua
Inglés
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FtsZ is a tubulin homolog in bacteria. It forms a Z-ring to recruit other proteins in the process of cell division through its GTPase activity. Amino acid sequence of FtsZ was obtained from uniprot database and used for the determination of primary and secondary structures by several online tools. Homology modeling was carried out by SWISS-MODEL and PHYRE2. The models were evaluated and quality assessment indicated that the model produced by SWISS-MODEL had better quality than PHYRE2. Therefore, SWISS-MODEL was used in docking twenty five natural products by AutoDock 4.2.6. Dunnianol, pebrellin, dalbinol and hederagenin had docking energy higher than the previously used berberine and sanguinarine. Analogs of Dunnianol were sketched by ChemBioOffice Ultra 11.0 and docked. The analogs 2,4 and 7 had higher docking energy than the original compound. These natural products and the analogs obtained in this study could serve as possible inhibitors of this cell division protein, a new target in the development of new antimicrobials.<br />

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APA 7

al, M. S. E. (2019). In Silico Structural Analysis of The Cell Division Protein, FtsZ: Screening Natural Products for Inhibitors. https://doi.org/10.33899/edusj.2019.160910

MLA

al, mohammed saeed et. "In Silico Structural Analysis of The Cell Division Protein, FtsZ: Screening Natural Products for Inhibitors." 2019. https://doi.org/10.33899/edusj.2019.160910.

Chicago

al, mohammed saeed et. 2019. "In Silico Structural Analysis of The Cell Division Protein, FtsZ: Screening Natural Products for Inhibitors.". https://doi.org/10.33899/edusj.2019.160910.

Harvard

al, M. S. E. 2019, In Silico Structural Analysis of The Cell Division Protein, FtsZ: Screening Natural Products for Inhibitors, University of Mosul, College of Education for Pure Science, available at: https://doi.org/10.33899/edusj.2019.160910 [Accessed 7 Aug. 2026].

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Titolo
In Silico Structural Analysis of The Cell Division Protein, FtsZ: Screening Natural Products for Inhibitors
Autore / collaboratori
mohammed saeed et al
Editore
University of Mosul, College of Education for Pure Science
Anno di pubblicazione
2019
ISSN
1812-125X
ISSN
1812-125X
Lingua
Inglés

Soggetti

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autodock 4.2.6; dunnianol; homology modeling; bioinformatics
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