Evaluation of possible adverse effects in broiler chickens supplemented with ibuprofen or meloxicam

ABSTRACT Antimicrobial Growth Promoters (AGPs) have been phased out due to their link to antibiotic resistance. While their exact mode of action remains unknown, they are thought to reduce inflammation in the gut. This study explored the safety and efficacy of two non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen (IBF) and meloxicam (MLX), as potential feed additives for broiler chickens. Chickens were divided into groups and fed diets supplemented with various doses of IBF or MLX for 42 days. Growth performance, blood parameters, and tissue health were monitored. While some minor changes in blood chemistry were observed, particularly a decrease in ALT levels and an increase in uric acid with IBF, these alterations were not considered clinically significant. Histopathological examination of vital organs revealed no signs of NSAID-induced damage. In conclusion, both IBF and MLX appear to be safe and well-tolerated as feed additives for broiler chickens, without negatively impacting growth performance or causing significant adverse effects.