The effect of diazepam in some fertility and testosterone levels in healthy adult male rats

Abstract<br /> The present investigation was conducted to reveal the effect of oral administration of diazepam (2.5-5 mg/kg B.W.) orally daily for 6 weeks on sperm concentration, the level of live sperm, dead and abnormal sperm and the relative weight of testis, prostate, seminal vesicles and epidydimus (head, body, tail). Furthermore measurement of testosterone hormone level in time interval (0,3,6 weeks) in adult albino male rats with age between 2.5-3 months and average body weight (222±16.79gram). The results showed that diazepam at doses (2.5-5 mg/kg) body weight caused a significant decreas in sperms count and the percentage of live sperms with a significant increased in the percentage of dead sperms and morphologically abnormal sperms. <br /> Furthermore a significant decreas in serum testosterone, average weight of testis, prostate glands and tail of epididymis associated with significant increased in average body weight during period 2,4,5,6, weeks in rats treated with diazepam at two doses 2.5,5 mg/kg of body weight compared with control group. It is concluded from the present study is that diazepam has adverse effect on sexual efficiency in adult male.