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Hallmarks of Cancer: New Dimensions

Douglas Hanahan · Cancer Discovery · 2022

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The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and disrupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogramming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added to the roster of functionally important cell types in the tumor microenvironment. SIGNIFICANCE: Cancer is daunting in the breadth and scope of its diversity, spanning genetics, cell and tissue biology, pathology, and response to therapy. Ever more powerful experimental and computational tools and technologies are providing an avalanche of "big data" about the myriad manifestations of the diseases that cancer encompasses. The integrative concept embodied in the hallmarks of cancer is helping to distill this complexity into an increasingly logical science, and the provisional new dimensions presented in this perspective may add value to that endeavor, to more fully understand mechanisms of cancer development and malignant progression, and apply that knowledge to cancer medicine.

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APA 7

Hanahan, D. (2022). Hallmarks of Cancer: New Dimensions. https://doi.org/10.1158/2159-8290.cd-21-1059

MLA

Hanahan, Douglas. "Hallmarks of Cancer: New Dimensions." 2022. https://doi.org/10.1158/2159-8290.cd-21-1059.

Chicago

Hanahan, Douglas. 2022. "Hallmarks of Cancer: New Dimensions.". https://doi.org/10.1158/2159-8290.cd-21-1059.

Harvard

Hanahan, D. 2022, Hallmarks of Cancer: New Dimensions, Cancer Discovery, available at: https://doi.org/10.1158/2159-8290.cd-21-1059 [Accessed 28 Jun. 2026].

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Título
Hallmarks of Cancer: New Dimensions
Autor / colaboradores
Douglas Hanahan
Editorial
Cancer Discovery
Año de publicación
2022
Idioma
en

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