Morphological abnormalities and histopathological lesions of ethyl alcohol During the embryonic development of the Swiss white mouse Mus Musculus

ABSTRACT<br /> The present study aims at investigating the effects of ethyl alcohol to induce morphological malformation and histological defects during the embryological eye development of the Swiss albino mice Mus musculus at the level of light microscope. The pregnant female ingested alcoholic solution orally as ascending concentrations (15%, 20%, 25%, 30%) daily, which started at the 7th of day pregnancy until delivery of neonate. The results revealed no pregnant period prolongation in contrast to control group, On the other hand, at (15%) conc. No morphological lesions were observed, while the histological malformations represented as retinal duplication and iris necrosis. At (20%)conc.(22%) of the embryos suffered from malformation (morphological and histological) which were represented in eye involution, adhering of corneal and retina to the lens, while at conc. (25%) the ratio of malformed embryos was (26%) represented in ophthalmocele and optic nerve necrosis. At (30%) conc. The ratio of malformed embryo reached to (32%), the features represented in the absence of left limb and the reduction of retinal layers with the absence of coronal stoma, compared with control group.