← Volver a resultados
Ficha bibliográfica · Consulta y acceso
Artículo

Phenolic and flavonoid content and in vitro inhibitory effect of some Amazonian fruit juices on CYP3A4 activity

Edna Márcia Almeida COSTA et al · Instituto Nacional de Pesquisas da Amazônia · 2022

Acceso abierto disponible
Lectura rápida. Revisá los datos básicos del recurso y luego accedé al contenido desde el botón principal. En esta ficha solo se muestra la información necesaria para identificar la obra, citarla y abrirla.
Publicación seriada

"Pinta" em população nativa do Estado do Amazonas

Esta publicación seriada contiene 218 contenidos relacionados.

Acceso al recurso

Entrá al contenido desde la opción principal o elegí otra fuente disponible.

Acceso principal

Acceso abierto disponible

Recurso identificado como acceso abierto, sin confirmar automáticamente si es texto completo directo.
Abrir recurso

Resumen

Descripción general del contenido del recurso.

ABSTRACT Many foods interact with drugs and may cause changes in the pharmacological effects of the co-administered therapeutic agent. The enzyme CYP3A4, which belongs to the cytochrome P450 enzyme complex, is responsible for the metabolism of most drugs currently on the market and is involved in many drug interactions. Hence, the interaction of this enzyme with juices of some fruits, such as grapefruit, can affect the pharmacokinetics of various drugs. However, native fruits from the Amazon region have not yet been the target of this type of research. We determined total polyphenols and flavonoids of the Amazonian fruits açaí (Euterpe precatoria), buriti (Mauritia flexuosa), camu-camu (Myrciaria dubia), cubiu (Solanum sessiliflorum), cupuaçu (Theobroma grandiflorum), jenipapo (Genipa americana), and taperebá (Spondias mombin) and evaluated the effects of each fruit juice on CYP3A4 activity, using the star fruit (Averrhoa carambola) juice as positive control. Açaí juice presented the highest content of total polyphenols and flavonoids (102.6 ± 7.2 µg gallic acid equivalent (GAE) per mL and 7.2 ± 0.6 µg quercetin equivalent (QE) per mL, respectively). All juices were able to inhibit the activity of CYP3A4. There was no residual activity of the drug-metabolizing enzyme for açai, buriti, cubiu, camu-camu, and taperebá juice, while for cupuaçu, jenipapo and the positive control, the residual activity was 44.3, 54.3 and 20.2%, respectively. Additional studies should identify the phytocompound(s) responsible for this inhibition activity, to clarify the mechanisms involved in this phenomenon.

Cómo citar

Elegí el formato que necesitás y copiá la referencia al portapapeles.

APA 7

al, E. M. A. C. E. (2022). Phenolic and flavonoid content and in vitro inhibitory effect of some Amazonian fruit juices on CYP3A4 activity. https://doi.org/10.1590/1809-4392202103642

MLA

al, Edna Márcia Almeida COSTA et. "Phenolic and flavonoid content and in vitro inhibitory effect of some Amazonian fruit juices on CYP3A4 activity." 2022. https://doi.org/10.1590/1809-4392202103642.

Chicago

al, Edna Márcia Almeida COSTA et. 2022. "Phenolic and flavonoid content and in vitro inhibitory effect of some Amazonian fruit juices on CYP3A4 activity.". https://doi.org/10.1590/1809-4392202103642.

Harvard

al, E. M. A. C. E. 2022, Phenolic and flavonoid content and in vitro inhibitory effect of some Amazonian fruit juices on CYP3A4 activity, Instituto Nacional de Pesquisas da Amazônia, available at: https://doi.org/10.1590/1809-4392202103642 [Accessed 28 Jun. 2026].

Compartir e imprimir

Guardá la ficha, copiá su enlace permanente o imprimila como PDF.

Exportar referencia

Si usás un gestor bibliográfico, podés exportar el registro en los formatos más comunes.

Detalles del recurso

Información bibliográfica útil para confirmar que se trata del material correcto.

Título
Phenolic and flavonoid content and in vitro inhibitory effect of some Amazonian fruit juices on CYP3A4 activity
Autor / colaboradores
Edna Márcia Almeida COSTA et al
Editorial
Instituto Nacional de Pesquisas da Amazônia
Año de publicación
2022
ISSN
0044-5967
ISSN
0044-5967
Idioma
eng

Materias

Explorá otros recursos relacionados a partir de estas materias.

Copiado