Indirect spetopotometric Assay of Paracetamol in Pharamaceutical Preparations Via Oxidative Coupling Reaction with 1-Naphthol and Metaperiodate

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Indirect spetopotometric Assay of Paracetamol in Pharamaceutical Preparations Via Oxidative Coupling Reaction with 1-Naphthol and Metaperiodate

Intisar K.Mohamad et al · University of Mosul, College of Education for Pure Science · 2005

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Autor / responsable

Intisar K.Mohamad et al

Editorial

University of Mosul, College of Education for Pure Science

Año

2005

ISSN

1812-125X

ISSN

1812-125X

Idioma

eng

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Development of indirect Spectrophotometric method for the determination of paracetamol in pure form as well as dosage form is described. The method is based on the acid hydrolysis of paracetamol to p-aminophenol followed by oxidative coupling reaction with 1-naphthol in the presence of sodium metaperiodate in alkaline medium to form a blue indophenol dye which absorbs at 600nm. Beer's law is obeyed in the concentrations range of 1.2-24 j.ig/ml with a molar absorptivity of 9.65 x 103 1. mol'1. cm"1., accuracy (average recovery) is 100.91% and precision (RSD) is less than 2.5%. Common excipients used as additives in pharmaceuticals do not interfere in the proposed method. The method is successfully employed for the determination of paracetamol in

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APA 7

al, I. K. E. (2005). Indirect spetopotometric Assay of Paracetamol in Pharamaceutical Preparations Via Oxidative Coupling Reaction with 1-Naphthol and Metaperiodate. https://doi.org/10.33899/edusj.2005.82408

MLA

al, Intisar K.Mohamad et. "Indirect spetopotometric Assay of Paracetamol in Pharamaceutical Preparations Via Oxidative Coupling Reaction with 1-Naphthol and Metaperiodate." 2005. https://doi.org/10.33899/edusj.2005.82408.

Chicago

al, Intisar K.Mohamad et. 2005. "Indirect spetopotometric Assay of Paracetamol in Pharamaceutical Preparations Via Oxidative Coupling Reaction with 1-Naphthol and Metaperiodate.". https://doi.org/10.33899/edusj.2005.82408.

Harvard

al, I. K. E. 2005, Indirect spetopotometric Assay of Paracetamol in Pharamaceutical Preparations Via Oxidative Coupling Reaction with 1-Naphthol and Metaperiodate, University of Mosul, College of Education for Pure Science, available at: https://doi.org/10.33899/edusj.2005.82408 [Accessed 3 Jul. 2026].

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Título: Indirect spetopotometric Assay of Paracetamol in Pharamaceutical Preparations Via Oxidative Coupling Reaction with 1-Naphthol and Metaperiodate

Autor / colaboradores: Intisar K.Mohamad et al

Editorial: University of Mosul, College of Education for Pure Science

Año de publicación: 2005

ISSN: 1812-125X

ISSN: 1812-125X

Idioma: eng

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spetopotometric assay; paracetamol; oxidative coupling